Gelatin based hemostatic agents are prepared from purified pork skin or bovine derived gelatine.They provide a mechanical matrix that promotes clotting and can be combined with topical thrombin.Gelatin based agents are available in sponge,powder or granular forms.Gelatin sponge in particular can absorb a large amount of blood and other fluids and can be useful in anorectal surgery,nasal bleeding,neurosurgery,urology.Gelatin matrices are able to adjust to irregular wounds and surgical cavities and are practical to use in minimally invasive procedures.Rare cases of abscess or granuloma formation have been reported with the use of gelatin based hemostatics.Floseal is a bovine derived granular matrix combined with human derived thrombin: the gelatin formulation ensures conformation to tissue surface and confined space and provides a matrix that promotes the formation of a stable clot.Floseal matrix has been successfully used in neurosurgery,thyroidectomy,orthopedic and cardiovascular surgery.A multicenter,prospective study avaluated the hemostatic effectiveness of an absorbable porcine gelatin in combination with human thrombin.Surgiflo,in patients undergoing endoscopic sinus sugery. The authors concluded that Surgiflo was clinically effective in controlling bleeding in irrigular wounds, such as those on mucosal surface after sinus surgery,in 96.7% of patients