Inline with this finding andrographolide exhibited hypoglycaemic effect in type 1 diabetic rats and other type 2 diabetic rats.
Reportedly andrograholide decreased the plasma glucose concentrations of STZ-diabetic rats (type 1 diabetic rats) through increased GLUT-4 in soleus muscle for the glucose uptake (glucose utilization) (Yu et al., 2003, 2008).
An andrographolide analogue namely andrographolide-lipoic acid conjugate was reported to lower the blood glucose levels through increasing insulin, preventing loss and dysfunction of islet beta cells and stimulating GLUT-4 membrane translocation in soleus muscles of alloxan-diabetic rats (type 1 diabetic rats) (Zhang et al., 2009)