Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular system
affect both directly and indirectly the function in a variety of organs, including the brain, with consequent
neurological (motor and sensory performance) and cognitive impairments, as well as leading to the development
of various psychiatric diseases. Post-stroke depression (PSD) is among the most frequent neuropsychiatric
consequences of cerebral ischemia. This review discusses several animal models used for the study of PSD and
summarizes recent findings in the genomic profile of the ageing brain, which are associated with age-related
disorders in the elderly. Since stroke and depression are diseases with increased incidence in the elderly, great
clinical benefit may especially accrue from deciphering and targeting basic mechanisms underlying PSD. Finally, we
discuss the relationship between ageing, circadian rhythmicity and PSD.
Ageing is associated with changes in the function of various organ systems. Changes in the cardiovascular systemaffect both directly and indirectly the function in a variety of organs, including the brain, with consequentneurological (motor and sensory performance) and cognitive impairments, as well as leading to the developmentof various psychiatric diseases. Post-stroke depression (PSD) is among the most frequent neuropsychiatricconsequences of cerebral ischemia. This review discusses several animal models used for the study of PSD andsummarizes recent findings in the genomic profile of the ageing brain, which are associated with age-relateddisorders in the elderly. Since stroke and depression are diseases with increased incidence in the elderly, greatclinical benefit may especially accrue from deciphering and targeting basic mechanisms underlying PSD. Finally, wediscuss the relationship between ageing, circadian rhythmicity and PSD.
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