One topical treatment, capsaicin, has had significant success, with almost 80% of patients experiencing some pain relief; however, the medication’s effect often does not occur until 2 weeks or more of therapy.
Capsaicin is derived from red peppers and is not recommended for placement on mucosa or open cutaneous lesions. Capsaicin has been associated with significant burning, stinging, and redness in 40% to 70% of patients, with up to 30% discontinuing therapy because of this side effect.
After use, patients must be warned to wash their hands and avoid contact with mucosal surfaces.