lowerinthevildagliptingroupeven1monthafterstudydrug withdrawal, indicating a robust improvement of glucose metabolism. Evaluation of OGTT-derived indices moreover showed improved glucose profile, due to the enhanced beta cell function with vildagliptin, but no change in insulin sensitivity in the short 3-month period. Previous studies have shown reduction of insulin resistance with vildagliptin, but after 52 weeks of treatment (44). After 1 month of discontinuing the treatment, the great majority of param- eters went back to baseline values, except the insulino- genic indices which remained slightly, though not significantly, elevated.