This can be observed from Figure H. show A number of eosinophilic granular cells and macrophages were observed either in the space between the host necrotic tissue and the fluke or in close contact to the parasite tegument The study reveals eosinophilic granular cells responding to metacercariae's ES antigen, suggesting a host immune response. The toxic products from the parasites' tegument might cause mechanical damage, potentially impairing the host's liver and pancreas functions upon infection with C. piscidium metacercariae.