At the initial visit, each subject was randomly treated with PCL to correct one NLF and NASHA to correct the contralateral fold. In addition to the choice of filler, the facial side treated was also randomly chosen. Injections were administered into the mid-deep dermis using a 27-G needle inserted at an approximate angle of 30° parallel to the length of fold. The initial injections were administered to obtain suboptimal augmentation of the folds. Folds were never overcorrected. None of the
patients received topical or local anesthetics.
After injection, the treated areas were gently massaged, so they conform to the contour of the surrounding tissue if necessary. If the treated area was swollen directly after the injection, an ice pack was applied on the site for a short period. Subjects were instructed to minimize exposure of the treated areas to excessive sun, UV lamp, and extreme cold weather until initial redness and swelling had resolved.