A. muricata is among the ethnomedicines employed to treat arthritic pain. An in vivo study on
different doses (3, 10, 30 and 100 mg/kg) of ethanolic extract from A. muricata leaves has investigated
the anti-arthritic activity in complete Freund’s adjuvant (CFA)-induced arthritis in rats. According to
the results, oral administration of the extract reduced the edema in a dose-dependent manner after two
weeks of injection. Because the extract at higher doses significantly suppressed TNF-α and IL-1β
expression in local tissue, the anti-arthritic activity of A. muricata leaves contributed to the suppression
of pro-inflammatory cytokines [78]. Hence, the anti-arthritic potential of A. muricata was substantiated
by the findings of this in vivo study