inhibited notonly the hemorrhagic activity,but also the proclotting activity of Bothrops jararaca and Bothrops jararacussu
venoms. These venoms induce a decrease in clotting time that
may be directly related to the proteolytic or thrombin-like activities. Previous studies have shown that some venom metalloproteases are “thrombin-like” enzymes that degrade coagulation
factors and,moreover,interact with the basal membrane and
vascular wall,inducing angiorrhexis and hemorrhage