for causing adverse health effects as a result of skin exposure.29 The NIOSH SK assignment involves use of scientific data on the physicochemical properties of a chemical, epidemiology, toxicology and data from mechanistic studies, and computational techniques, including predictive algorithms and mathematical models by means of analytical or numerical methods. Skin Notation Profiles are intended to inform occupational health practitioners, researchers, employers, and workers in potentially hazardous workplaces about potential health effects associated with dermal exposures, with the ultimate goal of better protecting workers from the risks of skin contact with hazardous chemi cals. Under the new NIOSH strategy, there are 47 published skin notation profiles expected by the end of 2014 with another 130 currently in the review process.