A prospective cohort of human immunodeficiency virus-1-infected patients who switched to mtDRV/rtv was followed for 2 years. Cellular IA was assessed according to HLA-DR and CD38 expression in CD4+ and CD8+ T-cells and their na€ıve, effector memory and central memory subpopulations, and systemic IA was evaluated according to sCD14 and D-dimer levels