It is also reasonable to believe that the number of mouse clicks varies to a large extent, depending on occupation, work task and the software used to carry out the work task. The combination of high repetitiveness in the fingers and wrist, the static loading imposed on the thumb to grip the mouse, the prolonged extension and ulnar deviation of the wrist and the long duration may all be contributing to the development of musculoskeletal symptoms in the forearm and hand/ wrist. Several studies have also found an increased risk for hand/wrist symptoms among individuals with long daily duration of VDU and computer mouse use [5,9,47,63].