Despite the clear need for more controlled studies in specific populations and targeting specific clinical out- comes, increasing blood EPA and DHA levels appears to have a generally positive impact on health, and aware- ness among the general population is high [18]. Because of this, the use of fish oil supplements has increased dramatically over the past decade, reaching sales of
$1.145 billion in 2011 and continuing to grow [19]. The
American Heart Association recommends an intake of
1 g/d of combined EPA and DHA from food or supple- ments for secondary prevention [20], and concentrated formulations of EPA and DHA are now available as both dietary supplements and medications.