This research is a study the measurement of heavy metals is includes arsenic (As) lead (Pb) mercury (Hg) cadmium (Cd) and chromium (Cr) in soil in the Sanambin Reservoir Non-Hunting Area wetland, Buriram province. Identify the soil sample points from land-use/land-cover and collected for different seasons on April (dry season soil) and August (rainy season soil). Soil samples were collected from topsoil (0-20 cm in depth) using a hand auger and digestion of soil samples by nitric acid–hydrochloric acid digestion for analysis by Fast Sequential AAS. The regression analysis to determine the actual relationship between the physical and chemical soil properties to the amount of heavy metals in the soil, the results showed that cation exchange capacity have an high influence in the amounts of heavy metals in the soil, there were significant statistical differences. The results dry season soil showed that the average concentrations of the heavy metals As 0.26 mg/kg Pb 15.86 mg/kg Hg 13.37 g/kg Cd 0.31 mg/kg and Cr 7.92 mg/kg. And the results rainy season soil showed that the average concentrations of the heavy metals As 0.38 mg/kg Pb 21.50 mg/kg Hg 42.69 g/kg Cd 0.65 mg/kg and Cr 11.70 mg/kg. Finally, a soil samples from dry season soil and rainy season soil have a lower than of soil quality standard for residential and agricultural use of heavy metals.