To overcome the potential risk of adverse effects and antibiotic resistance from synthetic drugs, plant extract have been extensively studied as alternative treatments for many diseases caused by their antimicrobial and antioxidant activity. Among various plant fruits contain many antimicrobial and antioxidant compounds, including tannins, flavonoids and phenolics. (Chanwitheesuk et al., 2005). Some indigenous fruits such as litchi, longan, pomegranate, pomelo, rambutan and mangosteen were consumed directly as fresh arils or were used in the food industry in the manufacture of concentrates, juices, and caned. These fruit peels are often the waste and effect to the environment they are gradually fermented and released off odors. Recently peel and seed of fruit were growing interest for their biological activity and the current study focuses on the possibility of using peel and seed waste as source of low-cost natural antioxidant and antimicrobial. This study aim at investigating and comparing the total phenolic, total flovonoid, free radical scavenging and anti-acne inducing bacteria activities of fruit peels commonly consumed and grown in Thailand.