Sixty two mice of both sexes of Swiss Albino mice having body
weight of 16-33 g, were obtained from Laboratory Animal
Housing Unit of National Veterinary Research Institute (NVRI),
VOM, Jos. They were kept at the Animal Housing Unit of
the Department of Pharmacology and Toxicology, Faculty of
Veterinary Medicine, Usmanu Danfodiyo University, Sokoto,
Nigeria. The consent of the ethical committee was obtained
from the veterinary research and ethical committee on the use of
Laboratory animal for research purposes of Usmanu Danfodiyo
University Sokoto, Nigeria. The animals were housed in standard
cages for 5 days prior to dosing to allow for acclimatization
to the laboratory conditions in accordance with the National
Institute of Health guideline for the care and use of Laboratory
animals