Internationally, the issue of ETO exposures from food has been considered in a qualitative sense, but no quantitative risk assessments have been published. The WHO concluded that significant oral exposure of humans to ETO residues from fumigations is unlikely,due to the rapid disappearance of the residues through evaporation and the rapid formation of stable breakdown products (WHO, 1985). The NTP (1998) cited a report by the Agency for Toxic Substance and Disease Registry (1990) that found there was no information indicating ETO is a common contaminant in food, but no studies were cited to support this conclusion.Researchers have also stated that it is not valid to conclude there is a cancer risk from minute quantities of ETO in spices, since the exposures to people are more than a million times lower than that used in animal studies (Doull, 1995). However, no published reports were found to substantiate these estimates, and it appears from the current study that exposures to ETO and its reaction products may be higher than previously believed. In addition, these opinions appear to discount
the possible contribution of ECH and EBH to potential cancer risk.
Internationally, the issue of ETO exposures from food has been considered in a qualitative sense, but no quantitative risk assessments have been published. The WHO concluded that significant oral exposure of humans to ETO residues from fumigations is unlikely,due to the rapid disappearance of the residues through evaporation and the rapid formation of stable breakdown products (WHO, 1985). The NTP (1998) cited a report by the Agency for Toxic Substance and Disease Registry (1990) that found there was no information indicating ETO is a common contaminant in food, but no studies were cited to support this conclusion.Researchers have also stated that it is not valid to conclude there is a cancer risk from minute quantities of ETO in spices, since the exposures to people are more than a million times lower than that used in animal studies (Doull, 1995). However, no published reports were found to substantiate these estimates, and it appears from the current study that exposures to ETO and its reaction products may be higher than previously believed. In addition, these opinions appear to discountthe possible contribution of ECH and EBH to potential cancer risk.
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