There have been many attempt to reduce membrane fouling and enhance the permeate flux the CFMF of wine Till now, a little is referenced in literature concerning the control the control of membrane fouling by mechanical or chemical techniques in enology. In conventional cross-flow microfiltration, high fluid velocities are generated necessary to induce high shear rates at the membrane surface in order to limit the growth of cake on the membrane. But, it generates large axial pressure gradients. These high velocities and pressure gradients require energy and cause large pressure drops along the membrane leading to a non-optimal membrane utilization. To improve the efficiency of the filtration process and maintain the state of cleanliness of the membrane filtering surfaces at an acceptable level during the filtration process, most of commercial filtration devices are equipped with a reverse filtering system. Back-flushing, backwashing and back-pulsing are all methods of operation in which the transmembrane pressure is periodically inverted by the use of a secondary pump, so that permeate flows back into the feed, lifting the fouling layer from the surface of the membrane. These steps are time consuming and adding up mechanical stress to the filtration devices resulting in a loss of capacity and efficiency of the equipment. Also, these techniques seem to be inefficient within the first 15 min of filtration (in-situ observations on industrial equipment) depending on wine composition, treatments during winemaking and operating conditions of filtration. [M]