Intragastric administration of 500.0 mg/kg bw of a 95% ethanol extract of the fruits to rats daily for 4 days, produced a significant inhibition of carrageenan-induced footpad oedema (50.0% reduction, P < 0.05), and cotton pellet-induced granulomas (25.0% reduction, P < 0.05) (29). Analgesic activity A hot aqueous extract of the fruits did not inhibit conduction in the frog sciatic nerve when added to the bath medium at a concentration of 2.0% (34). Intragastric administration of 500.0 mg/kg bw of a 95% ethanol extract of the fruits to mice reduced the responsiveness of mice in the hotplate and tail-fl ick tests, thereby demonstrating analgesic effects (29).