Design of Experiments (DOE) is a tool which allows formulators
to understand the effects of formulation variables on desired performance
outputs of the product. Using DOE, the relationship * Corresponding author.E-mail address: nalawadepravin@gmail.com (P.B. Nalawade).Contents lists available at ScienceDirectJournal of Drug Delivery Science and Technologyjournal homepage: www.elsevier.com/locate/jddsthttp://dx.doi.org/10.1016/j.jddst.2016.03.0121773-2247/© 2016 Elsevier B.V. All rights reserved.Journal of Drug Delivery Science and Technology 33 (2016) 75e87between different independent variables can be established andfinal product performance quality with respect to critical qualityattributes (CQAs) can be determined.