Animals exposed to a decreasing partial pressure of oxygen - hypoxia - are
traditionally categorized as either oxygen regulators or conformers. Regulators can
maintain their standard metabolic rate when exposed to hypoxia until the so-called
critical partial pressure of oxygen is reached. At further decreasing partial pressures of
oxygen, beyond the critical point, the metabolic rate will decrease and the animal will
start utilizing anaerobic metabolism with a concurrent accumulation of lactate (R in Fig.
1). Conformers, on the other hand, are not able to maintain standard metabolic rate during
hypoxia, and it will decrease linearly with decreasing partial pressure of oxygen (C in
Fig. 1). Metabolic rate versus hypoxia may also have a trace like T in Figure 1. – neither
a conformer nor a regulator, but a Typical trace that can be seen in many publications.
Reasons for this shape will be discussed below
Animals exposed to a decreasing partial pressure of oxygen - hypoxia - aretraditionally categorized as either oxygen regulators or conformers. Regulators canmaintain their standard metabolic rate when exposed to hypoxia until the so-calledcritical partial pressure of oxygen is reached. At further decreasing partial pressures ofoxygen, beyond the critical point, the metabolic rate will decrease and the animal willstart utilizing anaerobic metabolism with a concurrent accumulation of lactate (R in Fig.1). Conformers, on the other hand, are not able to maintain standard metabolic rate duringhypoxia, and it will decrease linearly with decreasing partial pressure of oxygen (C inFig. 1). Metabolic rate versus hypoxia may also have a trace like T in Figure 1. – neithera conformer nor a regulator, but a Typical trace that can be seen in many publications.Reasons for this shape will be discussed below
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