2.5. In Vitro Antiplasmodial Activity and Drug-Interaction
Tests. Dose-response assays and in vitro drug-interaction
studies were carried out to obtain the 50% inhibitory
concentrations (IC50) and 50% fraction inhibitory concentrations
(FIC50) of these bioactive compounds, AND,
CUR, and AS, respectively, as described earlier [3, 15].
Corresponding isobolograms (Figures 1(d) and 1(e)) were
constructed using the method reported earlier [3, 16].