Fortunately,
most antidepressants are effective in patients
with Parkinson disease.Bupropion (Wellbutrin)
is a dopamine reuptake inhibitor and
so increases the availability of dopamine, and
it should also have antiparkinsonian effects,
but unfortunately it does not. Conversely, selective
serotonin reuptake inhibitors (SSRIs)
theoretically can worsen or cause parkinsonism,
but evidence shows that they are safe to
use in patients with Parkinson disease. Some
evidence indicates that tricyclic antidepressants
may be superior to SSRIs for treating
depression in patients with Parkinson disease,
so they might be the better choice in patients
who can tolerate them.