This study was focused on extraction and
quantification of inorganic arsenic (iAs), the most toxic form. Arsenic speciation was carried out via LC
with both anionic and cationic exchange with ICP-MS detection (LC-ICP-MS). The detection limits (LODs),
quantification limits (LOQs), precision and accuracy for arsenic species were established. The proposed
method was evaluated using eight reference materials (RMs). Arsenobetaine was the main species found
in all samples. The total and iAs concentration in 22 seafood samples and RMs ranged between 0.27–35.2
and 0.02–0.71 mg As kg1, respectively. Recoveries ranging from 100% to 106% for iAs, based on spikes,
were achieved. The proposed method provides reliable iAs data for future risk assessment analysis.