Hox GENES IN VERTEBRATES
The vertebrate counterparts of the bithorax/antennapedia cluster are the Hox genes, usually found in four clusters . In man the four HOX gene clusters are located on different chromosomes, at 7p15, 17q21.2, 12q13, and 2q31. Each cluster consists of 13 paralog groups with nine to eleven members assigned on the basis of sequence similarity and relative position within the cluster. A high degree of homology is evident between the human HOX genes and the Hom-C genes of Drosophila, . Thus the human paralog groups 1–8 are more closely related to antennapedia , with groups 9–13 more closely related to abdominal-B.
Hox GENES IN VERTEBRATESThe vertebrate counterparts of the bithorax/antennapedia cluster are the Hox genes, usually found in four clusters . In man the four HOX gene clusters are located on different chromosomes, at 7p15, 17q21.2, 12q13, and 2q31. Each cluster consists of 13 paralog groups with nine to eleven members assigned on the basis of sequence similarity and relative position within the cluster. A high degree of homology is evident between the human HOX genes and the Hom-C genes of Drosophila, . Thus the human paralog groups 1–8 are more closely related to antennapedia , with groups 9–13 more closely related to abdominal-B.
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