Schematic drawing of the reactions related to malic acid secretion, including the significance and direction of transcriptional changes of the genes encoding the enzymes catalyzing those steps. The reaction arrows show the direction of the reaction stated in the GEM of A. oryzae. Double-headed arrows indicate reactions assumed to be reversible. The numbers next to the reaction arrows correlate with the reaction numbers in the model. The arrowed fields indicate the significance of transcriptional change in the comparison of the stationary phase to the exponential phase, with the ammonium condition indicated in the left set of boxes and the peptone condition indicated in the right set of boxes. The darker that the shading is, the more significant that the change is. The direction of transcriptional change is indicated by the direction of the arrows: up arrows, upregulation in stationary phase; down arrows, downregulation in stationary phase. Asterisks, data for the most significantly changed genes of an enzyme complex.