Orlistat is a drug with an increasingly widespread use due to obesity. Therefore, acute pancreatitis must be kept in mind when faced with newly developed abdominal pain in patients under orlistat treatment. In addition, imaging techniques (such as hepatobiliary ultrasound and abdominal computed tomography) should be requested. More attention must be paid when planning to prescribe orlistat to patients if there are risk factors for acute pancreatitis (alcohol use, height, serum calcium and lipid levels)