It was observed that Lesions in the muscle layer, of the ganglion cells, as well as the CICs, characterized by thinner intestinal muscles, were reduced in frequency of ICC and cells of the plexuses of Meissner and Auerbach, with similar intensity throughout the digestive tract, suggesting that lesions occurred with similar intensity throughout the gastrointestinal tract, with concomitant nerve injuries and muscle, impeding the adequate formation of the myenteric plexus and the intestinal muscles layer.