In support of his research or preparation of this manuscript, one of the authors (P.J.D.) received grants or outside funding from a Heart and Stroke Foundation of Canada/Canadian Institutes of Health Fellowship Award. The authors did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.