we can sort through some of what is true and that which is woo in this whole realm of mitochondrial dysfunction, insulin resistance, diabetes and all manner of "metabolic derangement". In the context of the electrochemistry involved we can sort through what impact, if any, the macronutrient composition of one's diet and/or its caloric content may have, and other factors like genetics that are at play. To the latter there is ever emerging peer review literature to discuss, but as to the relationship between diet and mitochondrial function, the waters are far more murky. I invite everyone, including detractors, to participate here in the comments as only by discussing these things and being challenged can we endeavor to arrive at the truth to the best that the available scientific evidence allows us.