One research letter described a patient in whom the QTc interval increased by 58 milliseconds when lansoprazole was added to ceftriaxone and 2 patients who received lansoprazole and ceftriaxone in a prospective cohort of 40 patients with torsade de pointes and sudden cardiac death.However, no conclusion could be drawn from these anecdotes. Our study furthers the knowledge by observing an increased risk of ventricular arrhythmia, cardiac arrest, and death when ceftriaxone was combined with lansoprazole.