D-limonene is rapidly distributed
to different tissues in the body and
is readily metabolized. D-limonene
and/or its metabolites are detectable
in serum, liver, lung, kidney, and many
other tissues,5 with higher concentrations
detected in adipose tissue and
mammary gland than in less fatty tissues.
7 The half-life of d-limonene in
humans has been estimated to be 12-
24 hours,7 and excretion occurs primarily
through the urine.5,6 No accumulation
of the metabolites was found
after repetitive dosing for 21 days.8