Frameworks that facilitate the aforementioned approaches have been developed. These include the “pain, agitation, and delirium” (PAD) guidelines44 and the “spontaneous awakening and breathing coordination, attention to the choice of sedation, delirium monitoring, and early mobility and exercise” (ABCDE) bundle.56 These guidelines emphasize improving team communication in the ICU, standardizing care processes, and prioritizing methods to lighten sedation and facilitate early mobilization and extubation. Each guideline recognizes the conceptual evolution from spontaneous-breathing trials and interruption of sedation to a comprehensive approach to monitoring and managing pain, agitation, and delirium.