Given the disease burden of PE, novel preventions, such
as folic acid, need to undergo proper scientific investigation.
The results obtained in the FACT trial will inform clinical
decision making by indicating whether daily supplementation
with 4.0mg folic acid starting in early pregnancy (8 to
16 weeks of gestation) until delivery is effective in preventing
PE and its associated adverse outcomes in women with
increased risk of developing PE. Follow-up studies for study
participants in this large trial can provide answer to the question
whether folic acid supplementation during pregnancy
has impact on long-term outcomes in the mothers and their
offspring.