Capsule containing EMR was given orally and the possibility of enzymatic degradation in alimentary tract and hepatic metabolism could not be excluded. Bioactive xanthone will theoretically circulate systemically throughout the body, but we do not have enough data concerning the fate of this substance in the body. Other possible explanation, might be due to the short duration of treatment. Three weeks application might be too short for natural source of antioxidant to come out with significant results, compared to synthetic (chemical) antioxidant. The remission of a chronic skin disease such as acne will need, about 11⁄2 up to 2 months. Multifactorial etiology of AV certainly affect the healing process.