No longterm
toxicity was reported in this analysis.[12] A Cochrane review
of RT + HT of rectal cancer revealed a survival benefit in HT +
RT arm as compared with RT alone. After 2 years, the difference
in overall survival between the two arms disappeared.[13] The
present study has also shown an improved response rate and
overall survival with RT + HT. Valdagni’s study published in
1988 also has shown a similar benefit.[4]