A major source of superoxide production and NO scavenging in the vascular wall is NAD(P)Hoxidase (NAD(P)Hox) (Brandes & Kreuzer, 2005; Silver et al. 2007), but substantial expression of this enzyme is assumed to only occur in obesity, cardiovascular pathology and ageing (Brandes & Kreuzer, 2005; Silver et al. 2007).