3.1. Isolation of a gram-negative and urease-negative bacterium
The histology of the gastric biopsy specimens indicated grandular
atrophy and intestinal metaplasia accompanied by infiltration
of mononuclear cells to the lamina propria, a typical observation in
gastric mucosa infected with H. pylori (Fig. 1A). Though it is not
specific, a few bacteria-like organisms could be seen in the gastric
lumen (Fig. 1B). H. pylori ureA gene was amplified in the paraffinembedded
gastric tissue (not shown).