To properly evaluate long-term sunscreen effectiveness in humans, evidence from randomized controlled trials is required, principally because observational studies of sunscreen use and skin cancer suffer from intractable confounding: the determinants of sunscreen use and of skin cancer, e.g., susceptibility to sunburn, high sun exposure (occupational/recreational), past history of skin cancer, are inseparable.
To properly evaluate long-term sunscreen effectiveness in humans, evidence from randomized controlled trials is required, principally because observational studies of sunscreen use and skin cancer suffer from intractable confounding: the determinants of sunscreen use and of skin cancer, e.g., susceptibility to sunburn, high sun exposure (occupational/recreational), past history of skin cancer, are inseparable.
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