Still, within the last 6 years, approximately 20 studies exploring qEEG or ERP correlates of response to treatment with acetylcholinesterase inhibitors have been published [65–67], many of these with encouraging results. For example, Babiloni et al [66] recently reported that persons with mild AD who were clinically responding to treatment with donepezil also showed restored temporal and occipital alpha rhythms in comparison to treatment nonresponders. Although this literature is nonetheless
smaller as a result of the currently limited range of marketed symptomatic therapies, there is no conceptual reason to suspect that one or more of the promising qEEG and/or ERP markers described above will not be sensitive to change (or a lack thereof), with novel and truly diseasemodifying
therapies yet to be discovered.