Characterizing the molecular properties of neoblasts and
their non-neoblast progeny is unquestionably an
important component of understanding the functioning
of these remarkable stem cells. However, current research
in stem-cell biology is providing increasing evidence that
the behaviors and fates of stem cells are not inherent,
cell-autonomous properties, but are instead critically
dependent on external cues and feedback control [11].
Thus, to obtain a complete picture of how neoblasts
function, it will be at least as important to understand the
undoubtedly complex inputs that are integrated by these
cells as they choose between alternative potential fates.