Periodontitis is a chronic inflammatory disease caused by microorganisms residing in subgingival biofilm. The disease is predominantly associated with colonization by Gram-negative anaerobic microorganisms. In particular, Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) has been known to be the major etiological agents of periodontitis [1–4]. The primary goal of periodontitis treatment is thus elimination of pathogen-containing biofilms. Supra- and subgingival mechanical debridement is the traditional initial step in treating periodontitis, even though the process is laborious and the results technique-dependent. In addition, mechanical debridement rarely leads to the complete removal of putative periodontal pathogens.