Honey is a natural product that shows potential effects to inhibit or suppress the development and progression of tumor and cancer. Honey is highly and selectively cytotoxic against tumor or cancer cells while it is non-cytotoxic to normal cells. It can inhibit cancerogenesis by modulating or interfering with the molecular processes or events of initiation, promotion, and progression stages. It, therefore, can be considered a potential and promising anticancer agent which warrants further research—both in experimental and clinical studies.