Despite this, another recent meta-analysis documented
a 31% reduction in the frequency of severe
cerebral hemorrhage through the use of magnesium
sulfate (31). This finding conflicts, however, with
the findings of an evaluation by the German
Neonatology Network (GNN) of 1965 preterm
neonates weighing less than 1500 grams: In this cohort,
the combination of fenoterol and magnesium
sulfate was found to be associated with the highest
rate of cerebral hemorrhage of all the tocolytic drugs
and drug combinations that were analyzed (32).