This paper aimed to develop a physiologically activated dried antimicrobial spray for foot deodorant and select the suitable components such as film forming agent, solvent, antimicrobial agent and flavoring agents. The evaporation rates, antimicrobial activity, spray pattern, viscosity and cooling effect were evaluated. The developed formulation exhibited the high evaporating rate, high antimicrobial activity, appropriate spray pattern, slightly viscous solution with cooling effect after spraying onto skin. The developed formulation exhibited the potential application as the rapidly dried antimicrobial spray for foot deodorant.