Osteocytes play an important role in the response of bone to
microdamage and mechanical stimuli, and regulate phosphate
metabolism through secretion of fibroblast growth factor-23.
When microdamage develops in bone, local osteocytes undergo
apoptosis, and signal to osteoclasts to begin bone resorption
and initiate the remodelling cycle. In the absence of viable
osteocytes, osteoclast activity is greatly increased, suggesting
that osteocytes may exert a tonic inhibitory action on resorption.
It has been proposed that osteocytes are the sensors of loading
and mechanical stimuli; as strain is applied to bone, fluid shear
in the canaliculi deforms the osteocyte dendrite cell membrane,
and initiates intracellular signalling.
Osteocytes play an important role in the response of bone tomicrodamage and mechanical stimuli, and regulate phosphatemetabolism through secretion of fibroblast growth factor-23.When microdamage develops in bone, local osteocytes undergoapoptosis, and signal to osteoclasts to begin bone resorptionand initiate the remodelling cycle. In the absence of viableosteocytes, osteoclast activity is greatly increased, suggestingthat osteocytes may exert a tonic inhibitory action on resorption.It has been proposed that osteocytes are the sensors of loadingand mechanical stimuli; as strain is applied to bone, fluid shearin the canaliculi deforms the osteocyte dendrite cell membrane,and initiates intracellular signalling.
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