Hepatocellular carcinoma (HCC) is the third leading cause of
cancer-related death worldwide [1]. Although new therapeutic
strategies have been continuously developed and applied
to clinical treatment of HCC, the prognosis is still very poor
[2]. The invasion and metastasis are one of the most important
reasons for the mortality of HCC [3].Therefore, understanding
the mechanisms that facilitate the invasion and
metastasis is critical for exploring new strategies for the treatment
of HCC.