The correlation between apoptosis, autophagy and necrosis and their pathologic processes in ischemic stroke is not clear. Some studies have shown that neurons at the core of ischemia tend to undergo necrosis, while neurons in the penumbra (surrounding region) are subjected to apoptosis (Sabri et al., 2013).
However, some in vivo experiments indicate that both apoptosis and autophagy are activated in the ischemic penumbra (Pamenter et al., 2012). Terminal deoxynucleotidyl transferase-mediated dUTP-biotinin situ nick end labeling (TUNEL) and propidium iodide (PI) are used as markers of apoptosis and necrosis, respectively (Unal Cevik and Dalkara, 2003).
The correlation between apoptosis, autophagy and necrosis and their pathologic processes in ischemic stroke is not clear. Some studies have shown that neurons at the core of ischemia tend to undergo necrosis, while neurons in the penumbra (surrounding region) are subjected to apoptosis (Sabri et al., 2013). However, some in vivo experiments indicate that both apoptosis and autophagy are activated in the ischemic penumbra (Pamenter et al., 2012). Terminal deoxynucleotidyl transferase-mediated dUTP-biotinin situ nick end labeling (TUNEL) and propidium iodide (PI) are used as markers of apoptosis and necrosis, respectively (Unal Cevik and Dalkara, 2003).
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