The increase of BP improving tissue perfusion of vital organs was reflected in significant decrease of blood lactate levels compared with those in the control group. Blood lactate levels may be used as an indicator for tissue perfusion during management of severe sepsis and septic shock [25]. In the 3-hour and 6-hour protocols in the guidelines [9], it is necessary to reverse anaerobic metabolism and low tissue perfusion in these patients as quickly as possible. After treatment with safflower yellow, blood lactate levels in the study group decreased significantly, suggesting safflower yellow improves the ischemia hypoxia and anaerobic glycolysis in septic shock.