In contrast to neurotrophin withdrawal-
induced PCD, these model systems typically cannot be rescued after
the initial insult and show no requirement for macromolecular synthesis
(e.g., Reference 184), the PCD observed after transfer of neurons to nondepolarizing
potassium concentrations being the notable exception.185,186 Typical
morphologic features of PCD, including neurite withdrawal, chromatin
condensation, plasma membrane blebbing, and nuclear fragmentation, are